 | Houston Texans | | |
| Date |
Opponent |
Time (ET) / Results |
TV |
Location |
| Sun. Sep 13 | New York | 1:00 PM | CBS | Reliant Stadium |
| Sun. Sep 20 | @ Tennessee | 1:00 PM | CBS | LP Field |
| Sun. Sep 27 | Jacksonville | 1:00 PM | CBS | Reliant Stadium |
| Sun. Oct 4 | Oakland | 1:00 PM | CBS | Reliant Stadium |
| Sun. Oct 11 | @ Arizona | 4:15 PM | CBS | U of Phoenix Stadium |
| Sun. Oct 18 | @ Cincinnati | 1:00 PM | CBS | Paul Brown Stadium |
| Sun. Oct 25 | San Francisco | 1:00 PM | FOX | Reliant Stadium |
| Sun. Nov 1 | @ Buffalo | 1:00 PM | CBS | Ralph Wilson Stadium |
| Sun. Nov 8 | @ Indianapolis | 1:00 PM | CBS | Lucas Oil |
| Mon. Nov 23 | Tennessee | 8:30 PM | ESP | Reliant Stadium |
| Sun. Nov 29 | Indianapolis | 1:00 PM | CBS | Reliant Stadium |
| Sun. Dec 6 | @ Jacksonville | 1:00 PM | CBS | Jacksonville Stadium |
| Sun. Dec 13 | Seattle | 1:00 PM | FOX | Reliant Stadium |
| Sun. Dec 20 | @ St. Louis | 1:00 PM | CBS | Edward Jones Dome |
| Sun. Dec 27 | @ Miami | 1:00 PM | CBS | Dolphin Stadium |
| Sun. Jan 3 | New England | 1:00 PM | CBS | Reliant Stadium |
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