 | San Francisco 49ers | | |
| Date |
Opponent |
Time (ET) / Results |
TV |
Location |
| Sun. Sep 7 | Arizona | 4:15 PM | FOX | Monster Park |
| Sun. Sep 14 | @ Seattle | 4:05 PM | FOX | Qwest Field |
| Sun. Sep 21 | Detroit | 4:05 PM | FOX | Monster Park |
| Sun. Sep 28 | @ New Orleans | 1:00 PM | FOX | Superdome |
| Sun. Oct 5 | New England | 4:15 PM | CBS | Monster Park |
| Sun. Oct 12 | Philadelphia | 4:15 PM | FOX | Monster Park |
| Sun. Oct 19 | @ New York | 1:00 PM | FOX | Giants Stadium |
| Sun. Oct 26 | Seattle | 4:15 PM | FOX | Monster Park |
| Mon. Nov 10 | @ Arizona | 8:30 PM | ESP | U of Phoenix Stadium |
| Sun. Nov 16 | St. Louis | 4:05 PM | FOX | Monster Park |
| Sun. Nov 23 | @ Dallas | 1:00 PM | FOX | Texas Stadium |
| Sun. Nov 30 | @ Buffalo | 1:00 PM | FOX | Ralph Wilson Stadium |
| Sun. Dec 7 | New York | 4:05 PM | CBS | Monster Park |
| Sun. Dec 14 | @ Miami | 1:00 PM | FOX | Dolphin Stadium |
| Sun. Dec 21 | @ St. Louis | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Dec 28 | Washington | 4:15 PM | FOX | Monster Park |
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