 | St. Louis Rams | | |
| Date |
Opponent |
Time (ET) / Results |
TV |
Location |
| Sun. Sep 7 | @ Philadelphia | 1:00 PM | FOX | Lincoln Financial Field |
| Sun. Sep 14 | New York | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Sep 21 | @ Seattle | 4:05 PM | FOX | Qwest Field |
| Sun. Sep 28 | Buffalo | 4:05 PM | CBS | Edward Jones Dome |
| Sun. Oct 12 | @ Washington | 1:00 PM | FOX | FedEx Field |
| Sun. Oct 19 | Dallas | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Oct 26 | @ New England | 1:00 PM | FOX | Gillette Stadium |
| Sun. Nov 2 | Arizona | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Nov 9 | @ New York | 1:00 PM | FOX | Giants Stadium |
| Sun. Nov 16 | @ San Francisco | 4:05 PM | FOX | Monster Park |
| Sun. Nov 23 | Chicago | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Nov 30 | Miami | 1:00 PM | CBS | Edward Jones Dome |
| Sun. Dec 7 | @ Arizona | 4:15 PM | FOX | U of Phoenix Stadium |
| Sun. Dec 14 | Seattle | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Dec 21 | San Francisco | 1:00 PM | FOX | Edward Jones Dome |
| Sun. Dec 28 | @ Atlanta | 1:00 PM | FOX | Georgia Dome |
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